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Cat. No.: HY-187874

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Zecdarasib

Name: Zecdarasib
Brand: MedChemExpress
SKU: HY-187874
Availability: PreOrder

(Synonyms: INCB161734)

Zecdarasib is an orally active Kirsten rat sarcoma virus oncogene homolog (KRAS) inhibitor with antitumor activity. Zecdarasib can be used in tumor-related research.

For research use only. We do not sell to patients.

CAS No.: 3080960-85-3
Formula: C₃₅H₃₂Cl₂FN₅O
Molecular Weight:628.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zecdarasib Chemical Structure

CAS No.: 3080960-85-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Zecdarasib is an orally active Kirsten rat sarcoma virus oncogene homolog (KRAS) inhibitor with antitumor activity. Zecdarasib can be used in tumor-related research^[1].

IC₅₀ & Target

^[1]

K-RAS

All Ras Isoforms :

In Vitro

Cell Cycle RegulationApoptosisOthers

Cell Cycle Regulation

Zecdarasib (INCB161734) induces S-phase inhibition in G12D HPAC cells with an IC₅₀ of 12.8 nM^[2].

Apoptosis

Zecdarasib induces caspase 3/7 cleavage in G12D HPAC cells, EC₅₀ < 100 nM^[2].

Others

Zecdarasib (INCB161734) binds both the GDP and GTP forms of G12D with picomolar K_D values^[2].
Zecdarasib potently inhibits SOS1-dependent GDP/GTP exchange with an IC₅₀ < 3 nM^[2].
Zecdarasib inhibits the KRAS downstream ERK signaling pathway in G12D mutant cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Zecdarasib (INCB161734) (oral) exhibits potent in vivo antitumor activity in multiple G12D-mutant tumor models^[2].
Zecdarasib (oral) produces sustained near-maximal KRAS inhibition in G12D HPAC mouse xenograft tumors, persisting for nearly the entire dosing interval^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

CAS No. 3080960-85-3
Molecular Weight 628.57
Formula C₃₅H₃₂Cl₂FN₅O
SMILES

N#CCCC1=CC2=C(N=C(C3=C2N(C([C@@]4(N(C(C5CC5)=O)[C@@]6(C[C@@]6(C4)[H])[H])[H])=C3)[C@]7([C@]8(CN[C@@]7(C8)[H])[H])[H])C)C(F)=[C@]1[C@]9=C(Cl)C(Cl)=CC=C9
Synonyms

INCB161734
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN) — Proposed INN: List 135. WHO Drug Information. 2026; 40(2).

[2]. Farren MR, et al. Abstract 5900: INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor demonstrates antitumor activity in KRAS G12D mutant tumors. *Cancer Res*. 2024;84(6_Suppl):5900.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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