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Cat. No.: HY-188059

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Zocilurtatug pelitecan

Name: Zocilurtatug pelitecan
Brand: MedChemExpress
SKU: HY-188059
Price: 960.00 USD
Availability: PreOrder

(Synonyms: ZL-1310)

Zocilurtatug pelitecan (ZL-1310) is a blood-brain barrier-penetrating antibody-drug conjugate targeting DLL3. It consists of the antibody component Zocilurtatug (HY-P992148) and the toxin-linker molecule DL-01 (HY-155870). Zocilurtatug pelitecan induces cell cycle arrest and apoptosis in tumor cells, and inhibits the growth of established human tumors in xenograft models. It can be used in research on extensive-stage small cell lung cancer (SCLC) and neuroendocrine tumors.

For research use only. We do not sell to patients.

CAS No.: 3058592-88-1

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Please store the product under the recommended conditions in the Certificate of Analysis.

Zocilurtatug pelitecan Chemical Structure

CAS No.: 3058592-88-1

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Biological Activity

Description

All Topoisomerase Isoforms :

In Vitro

Anti-cancerCell Cycle RegulationApoptosis

Anti-cancer

Cell Cycle Regulation

Apoptosis

Zocilurtatug pelitecan (ZL-1310) binds specifically to DLL3 across species but not other Delta family members, and induces internalization, cell cycle arrest, and apoptosis in DLL3-expressing tumor cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

ZL-1310 (administered intravenously) exhibits dose-dependent inhibition of tumor growth in CDX and PDX mouse models of DLL3-positive small cell lung cancer, with significant intratumoral accumulation of the cytotoxic payload; additionally, it shows stable pharmacokinetic profiles and acceptable tolerability in GLP toxicology studies conducted in rats and non-human primates^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 3058592-88-1
SMILES

[Zocilurtatug pelitecan]
Synonyms

ZL-1310
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin, L. N., et al. (2024). 241P Development and characterization of a novel DLL3-targeting antibody drug conjugate (ADC) for the treatment of solid tumors. ESMo Open, 9.

[2]. Dowlati, A., et al. (2026). A randomized, open-label, phase 3 study of ZL-1310, a DLL3 antibody-drug conjugate (ADC), compared to investigator’s choice therapy in participants with relapsed small cell lung cancer (DLLEVATE).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Zocilurtatug pelitecan

All Topoisomerase Isoforms