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United States

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Cat. No.: HY-185742

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ZW-251

ZW-251 is a glypican-3 (GPC3)-targeted antibody-drug conjugate (ADC) with topoisomerase-I inhibitory activity. ZW-251 induces cytotoxicity, penetrates tumor spheroids, exerts bystander cytotoxicity, and inhibits tumor growth in hepatocellular carcinoma models. ZW-251 can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZW-251 Chemical Structure

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Topoisomerase I

All Topoisomerase Isoforms :

In Vitro

ZW-251 (0.001-100 nM; 4 days) exhibits cell cytotoxicity to HepG2 spheroid liver cancer cell line^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2
Cynomolgus Monkey^[2]	20 mg/kg	i.v.	110.4 h
Cynomolgus Monkey^[2]	60 mg/kg	i.v.	115.2 h
Cynomolgus Monkey^[2]	120 mg/kg	i.v.	129.6 h

In Vivo

ZW-251 (20-120 mg/kg; i.v.; 3 doses at day 1, 22 and 43) is well tolerated in cynomolgus monkeys and exhibits dose-proportional PK^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys
^[2]
Dosage:

20 mg/kg; 60 mg/kg; 120 mg/kg
Administration:

i.v.; 3 doses at day 1, 22 and 43
Result:

Was well tolerated in cynomolgus monkeys.
Exhibited dose-proportional PK.

Related Protocols :

Chemical Information

SMILES

[ZW-251]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chandana, et al. A phase 1, first-in-human, multicenter study of ZW251, a novel glypican-3 (GPC3)–targeted antibody-drug conjugate (ADC), in participants with hepatocellular carcinoma (HCC). J Clin Oncol. 2026 Jan 12;44(Number 2_Suppl):TPS608.

[2]. Madera L, et al. ZW251, a novel glypican-3-targeting antibody-drug conjugate bearing a topoisomerase I inhibitor payload, demonstrates compelling preclinical activity in hepatocellular carcinoma models. 2024.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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