β-Zearalanol-d4
β-Zearalanol-d4 is the deuterated-labeled β-Zearalenol (HY-N6741). β-Zearalenol is a zearalenone metabolite and Estrogen receptor binder (Kd = 0.406 nM) that induces apoptosis through activation of p53, JNK, and p38 kinases and the mitochondrial apoptosis pathway, while inhibiting CYP19A1 and inducing autophagy via SIRT1. β-Zearalenol is used in research on cardiotoxicity, mycotoxin-induced reproductive toxicity, and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1778735-09-3
- Formula: C18H22D4O5
- Molecular Weight:326.42
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Biological Activity
Description
|
Estrogen receptor 0.406 nM (Kd) |
JNK |
p38 |
CYP19A1 |
SIRT1 |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1778735-09-3
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Unlabeled CAS 71030-11-0
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Appearance Solid
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Molecular Weight 326.42
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Formula C18H22D4O5
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Color White to off-white
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SMILES
OC1=C2C(CCCCC([2H])([2H])[C@@H](C([2H])([2H])CC[C@@H](OC2=O)C)O)=CC(O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
[3]. Yang F, et al. Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells. Environmental toxicology and pharmacology. 2019 May;68:52-60. [Content Brief]
[10]. Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicology mechanisms and methods. 2018 May;28(4):239-242. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- β-Zearalanol-d4
- 1778735-09-3
- Isotope-Labeled Compounds
- Drug Metabolite
- Estrogen Receptor/ERR
- MDM-2/p53
- JNK
- p38 MAPK
- Apoptosis
- Cytochrome P450
- Sirtuin
- Autophagy
- RAW264.7 macrophages
- human BeWo cells
- primary bovine ovarian granulosa cells
- Vero cells
- porcine endometrial cells
- human Caco-2 cells
- MCF-7 cells
- H9c2 cells
- HCT116 cells
- human CYP19A1
- Inhibitor
- inhibitor
- inhibit