12-Crown-4
Based on 1 Customer Validation
12-Crown-4 is a sodium-selective Na+/K+ permeability enhancer, amyloid-β aggregation inhibitor, and phase-transfer catalyst and lithium complexing agent. 12-Crown-4 produces high-dose tremor, convulsions, and peripheral neuromuscular stimulation. 12-Crown-4 binds Aβ40 monomers, stabilizes the monomers, and inhibits secondary structure changes/misfolding; it binds Aβ42, stabilizes the helical region, inhibits secondary structure changes, and restricts the conformational space. 12-Crown-4 can be used in research on neurological diseases such as Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 294-93-9
- Formula: C8H16O4
- Molecular Weight:176.21
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Storage:
RT, sealed storage, away from moisture and light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 294-93-9
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Appearance Liquid (Density: 0.995±0.06 g/cm3)
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Molecular Weight 176.21
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Formula C8H16O4
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Color Colorless to light yellow
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SMILES
C1COCCOCCOCCO1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, sealed storage, away from moisture and light
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
DMSO : ≥ 200 mg/mL (1135.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (292 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6750 mL | 28.3752 mL | 56.7505 mL | 141.8762 mL |
| 5 mM | 1.1350 mL | 5.6750 mL | 11.3501 mL | 28.3752 mL | |
| 10 mM | 0.5675 mL | 2.8375 mL | 5.6750 mL | 14.1876 mL | |
| 15 mM | 0.3783 mL | 1.8917 mL | 3.7834 mL | 9.4584 mL | |
| 20 mM | 0.2838 mL | 1.4188 mL | 2.8375 mL | 7.0938 mL | |
| 25 mM | 0.2270 mL | 1.1350 mL | 2.2700 mL | 5.6750 mL | |
| 30 mM | 0.1892 mL | 0.9458 mL | 1.8917 mL | 4.7292 mL | |
| 40 mM | 0.1419 mL | 0.7094 mL | 1.4188 mL | 3.5469 mL | |
| 50 mM | 0.1135 mL | 0.5675 mL | 1.1350 mL | 2.8375 mL | |
| 60 mM | 0.0946 mL | 0.4729 mL | 0.9458 mL | 2.3646 mL | |
| 80 mM | 0.0709 mL | 0.3547 mL | 0.7094 mL | 1.7735 mL | |
| 100 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.4188 mL |
12-Crown-4 Related Classifications
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