294-93-9
294-93-9
Chemical Structure
12-Crown-4
- CAS No.: 294-93-9
- Formula:C8H16O4
- Molecular Weight:176.21
IUPAC Name: 1,4,7,10-tetraoxacyclododecane
InChIKey: XQQZRZQVBFHBHL-UHFFFAOYSA-N
SMILES: C1COCCOCCOCCO1
Biological Activity: 12-Crown-4 is a sodium-selective Na+/K+ permeability enhancer, amyloid-β aggregation inhibitor, and phase-transfer catalyst and lithium complexing agent. 12-Crown-4 produces high-dose tremor, convulsions, and peripheral neuromuscular stimulation. 12-Crown-4 binds Aβ40 monomers, stabilizes the monomers, and inhibits secondary structure changes/misfolding; it binds Aβ42, stabilizes the helical region, inhibits secondary structure changes, and restricts the conformational space. 12-Crown-4 can be used in research on neurological diseases such as Alzheimer's disease[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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12-Crown-4 | 98.0% | 12-Crown-4 is a sodium-selective Na+/K+ permeability enhancer, amyloid-β aggregation inhibitor, and phase-transfer catalyst and lithium complexing agent. 12-Crown-4 produces high-dose tremor, convulsions, and peripheral neuromuscular stimulation. 12-Crown-4 binds Aβ40 monomers, stabilizes the monomers, and inhibits secondary structure changes/misfolding; it binds Aβ42, stabilizes the helical region, inhibits secondary structure changes, and restricts the conformational space. 12-Crown-4 can be used in research on neurological diseases such as Alzheimer's disease. | ||||||||||||||||||||
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(S)-Tetrahydrofuran-3-ol | 99.94% | (S)-Tetrahydrofuran-3-ol ((+)-3-Hydroxytetrahydrofuran) is a secondary alcohol and the (S)-enantiomer of Tetrahydrofuran-3-ol. (S)-Tetrahydrofuran-3-ol serves as a crucial chiral alcohol intermediate for the human immunodeficiency virus inhibitor Amprenavir (HY-17430). (S)-Tetrahydrofuran-3-ol is applicable to researches on chiral biocatalysis and synthesis of HIV protease inhibitor intermediates. | ||||||||||||||||||||
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(Tetrahydro-2H-pyran-4-yl)methanol | 98.58% | (Tetrahydro-2H-pyran-4-yl)methanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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15-Crown-5 | 99.19% | 15-Crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Cryptand 2.2.2 (Standard) | ≥98% | Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn2+, Co2+, Ni2+, Cu2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on. | ||||||||||||||||||||
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1,3-Dioxan-5-ol (Standard) | ≥98% | 1,3-Dioxan-5-ol (Standard) is the analytical standard of 1,3-Dioxan-5-ol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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2-(Bromomethyl)-1,3-dioxolane | 2-(Bromomethyl)-1,3-dioxolane is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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Diglycolic anhydride | 98.0% | 1,4-Dioxane-2,6-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Diaza-15-crown-5 | Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time. | |||||||||||||||||||||
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References
- [1]. Basok SS, et al. Synthesis, Biological Evaluation, and Molecular Modeling of Aza-Crown Ethers. Molecules (Basel, Switzerland). 2021 Apr 12;26(8):2225.
- [2]. Gad SC, et al. Thirteen cationic ionophores: their acute toxicity, neurobehavioral and membrane effects. Drug and chemical toxicology. 1985;8(6):451-68.
- [3]. Zhang H, et al. Small Molecule-Based Highly Active and Selective K Transporters with Potent Anticancer Activities. Nano letters. 2021 Feb 10;21(3):1384-1391.
- [4]. Agrawal N, et al. 12-Crown-4 Ether Disrupts the Patient Brain-Derived Amyloid-β-Fibril Trimer: Insight from All-Atom Molecular Dynamics Simulations. ACS chemical neuroscience. 2016 Oct 19;7(10):1433-1441.
- [5]. Agrawal N, et al. Binding of 12-Crown-4 with Alzheimer's Aβ40 and Aβ42 Monomers and Its Effect on Their Conformation: Insight from Molecular Dynamics Simulations. Molecular pharmaceutics. 2018 Jan 02;15(1):289-299.
