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Cat. No.: HY-149551

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17(R)-Protectin D1

Name: 17(R)-Protectin D1
Brand: MedChemExpress
SKU: HY-149551
Availability: PreOrder

(Synonyms: 17-epi-Protectin D1)

17(R)-Protectin D1 (17-epi-Protectin D1) is a protectin-family-specific pro-resolving lipid mediator derived from DHA (HY-B2167) and generated via Aspirin (HY-14654) triggering, possessing pro-inflammatory resolution, neuroprotective, and other activities. 17(R)-Protectin D1 is also the 17R-epimer of Protectin D1 (HY-130413). 17(R)-Protectin D1 enhances macrophage phagocytosis of Escherichia coli and limits neutrophil infiltration. 17(R)-Protectin D1 attenuates stroke severity in animal models. 17(R)-Protectin D1 can be used in research related to peritonitis and stroke.

For research use only. We do not sell to patients.

CAS No.: 1365694-03-6
Formula: C₂₂H₃₂O₄
Molecular Weight:360.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

17(R)-Protectin D1 Chemical Structure

CAS No.: 1365694-03-6

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- In Vitro
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Biological Activity

Description

In Vitro

Innate ImmunityBacterial InfectionLipid Inflammatory Mediators

Innate Immunity

Bacterial Infection

Lipid Inflammatory Mediators

17(R)-Protectin D1 (17-epi-Protectin D1) (10 pM; 15 min pre-incubation) increases phagocytosis of E. coli in human monocyte-derived macrophages, with a 2.26-fold higher initial internalization rate from 0-30 minutes and approximately 61% higher phagocytosis at 60 minutes compared with vehicle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityLipid Inflammatory MediatorsOthers

Innate Immunity

Lipid Inflammatory Mediators

17(R)-Protectin D1 (17-epi-neuroprotectin D1/17-epi-protectin D) (1-100 ng; i.v.; single injection immediately after Zymosan (HY-W250113) induction) limits leukocyte infiltration into the peritoneal cavity in Zymosan-induced peritonitis in mice and significantly reduces neutrophils^[1].

Others

17(R)-Protectin D1 (17-epi-Protectin D1) is an SPM epimer generated from DHA (HY-B2167) induced by Aspirin (HY-14654), with a longer duration of action in vivo, and can attenuate stroke severity in animal models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

FVB (male, 6-8 weeks old, approximately 23 g)^[1]
Dosage:

100 ng, 10 ng, or 1 ng
Administration:

i.v.; single injection immediately after Zymosan induction
Result:

Reduced total peritoneal‑exudate leukocyte counts across all three administered doses six hours post‑peritonitis induction; diminished neutrophil numbers by an average of ~72 % at the 10 ng dose, and lowered monocyte counts relative to the Zymosan‑vehicle control group.

Related Protocols :

Chemical Information

CAS No. 1365694-03-6
Molecular Weight 360.49
Formula C₂₂H₃₂O₄
SMILES

CC/C=C\C[C@@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
Synonyms

17-epi-Protectin D1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hamidzadeh K, et al. A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution. Biochemical pharmacology. 2022 Sep;203:115181.

[2]. Fredman G, et al. Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease. Nature reviews. Cardiology. 2024 Nov;21(11):808-823.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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