2-Bromo-4-fluorophenol
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2-Bromo-4-fluorophenol is a halophenol compound containing bromine and fluorine substituents, and is also a bromofluorophenol synthesis intermediate and building block.
For research use only. We do not sell to patients.
- CAS No.: 496-69-5
- Formula: C6H4BrFO
- Molecular Weight:191.00
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
2-Bromo-4-fluorophenol (5 mg/L; 120 min) achieved optimal oxidation via 0.2 U/mL laccase-catalyzed oxidation at pH 6.0 and 308 K, generating hydroxylated/coupled products as well as halogenated benzoquinone/acid derivatives[1].
2-Bromo-4-fluorophenol (5.0 g; 1 h at -60 °C) was converted to fluorosalicylaldehyde via n-BuLi-mediated lithium-halogen exchange and DMF formylation in 81% yield[2].
2-Bromo-4-fluorophenol (2.10 g (11 mmol); 2.5 h total) was reacted with 4,5,7-trichloroquinoline in NMP/aqueous NaOH to give 4-(2-bromo-4-fluorophenoxy)-5,7-dichloroquinoline (5) in 56% yield[5].
2-Bromo-4-fluorophenol (2.10 g (11 mmol); 6 h total) was reacted with 4,7-dichloroquinoline in NMP/aqueous NaOH to give 4-(2-bromo-4-fluorophenoxy)-7-chloroquinoline (6) in 43% yield[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 496-69-5
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Appearance Solid
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Molecular Weight 191.00
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Formula C6H4BrFO
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Color Off-white to pale purple
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SMILES
FC1=CC=C(C(Br)=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[6]. Gu SX, et al. Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & medicinal chemistry. 2011 Jul 15;19(14):4220-6. [Content Brief]
[8]. Akama T, et al. Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent. Bioorganic & medicinal chemistry letters. 2013 Mar 15;23(6):1680-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Bromo-4-fluorophenol Related Classifications
HY-W003971 Related Classifications
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