496-69-5
496-69-5
Chemical Structure
2-Bromo-4-fluorophenol
- CAS No.: 496-69-5
- Formula:C6H4BrFO
- Molecular Weight:191.00
IUPAC Name: 2-bromo-4-fluorophenol
InChIKey: MEYRABVEYCFHHB-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(Br)=C1)O
Biological Activity: 2-Bromo-4-fluorophenol is a halophenol compound containing bromine and fluorine substituents, and is also a bromofluorophenol synthesis intermediate and building block[1][2][3][4][5][6][7][8].
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2-Bromo-4-fluorophenol | 2-Bromo-4-fluorophenol is a halophenol compound containing bromine and fluorine substituents, and is also a bromofluorophenol synthesis intermediate and building block. | |||||||||||||||||||||
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References
- [1]. Dai Y, et al. Treatment of halogenated phenolic compounds by sequential tri-metal reduction and laccase-catalytic oxidation. Water research. 2015 Mar 15;71:64-73.
- [2]. Charles W, et al. Zr-Catalyzed Kinetic Resolution of Allylic Ethers and Mo-Catalyzed Chromene Formation in Synthesis. Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol. Journal American Chemical Society 26 August 1998; 120 (33): 8340-8347.
- [3]. Koerts J, et al. Influence of substituents in fluorobenzene derivatives on the cytochrome P450-catalyzed hydroxylation at the adjacent ortho aromatic carbon center. Chemical research in toxicology. 1997 Mar;10(3):279-88.
- [4]. Graham E, et al. Successful Development and Scale-up of a Palladium-Catalysed Amination Process in the Manufacture of ZM549865. Org. Process Res. Dev. 19 November 2004; 8 (6): 925-930.
- [5]. Johnson P, et al. Improved synthetic route to quinoxyfen photometabolite 2-chloro-10-fluorochromeno[2,3,4-de]quinoline. Pest Manag Sci. 2017 Aug;73(8):1703-1708.
- [6]. Gu SX, et al. Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & medicinal chemistry. 2011 Jul 15;19(14):4220-6. [Content Brief]
- [7]. Zhang H, et al. Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression. European journal of medicinal chemistry. 2015 Jan 07;89:524-39.
- [8]. Akama T, et al. Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent. Bioorganic & medicinal chemistry letters. 2013 Mar 15;23(6):1680-3. [Content Brief]
