308-R hydrochloride
Based on 1 Customer Validation
308-R hydrochloride is a SGK3/SGK1/S6K1 inhibitor. 308-R hydrochloride exhibits an IC50 of 5 nM against human SGK3, an IC50 of 10 nM against human SGK1, and an IC50 of 1 nM against human S6K1. 308-R hydrochloride can be used in breast cancer research. 308-R hydrochloride is also applicable to studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC SGK3 degrader-2 (HY-176823).
For research use only. We do not sell to patients.
- CAS No.: 2832888-22-7
- Formula: C23H24ClFN6O4S
- Molecular Weight:534.99
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SGK3 5 nM (IC50) |
SGK1 10 nM (IC50) |
S6K1 1 nM (IC50) |
In Vitro
308-R potently inhibits SGK3, SGK1, and S6K1 kinases in vitro with IC50 values of 5 nM, 10 nM, and 1 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:1 μM (basal conditions); 1 μM (combination with Akt inhibition)
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Incubation Time:8 h (basal conditions); 8 h (combination with Akt inhibition)
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Result:Exerted minimal effect on phosphorylation of NDRG1 at Thr346 under basal conditions without Akt inhibition.
Markedly suppressed phosphorylation of NDRG1 at Thr346 in the presence of Akt inhibition.
Chemical Information
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CAS No. 2832888-22-7
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Appearance Solid
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Molecular Weight 534.99
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Formula C23H24ClFN6O4S
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SMILES
CC1=CC=C(C(S(=O)(NC2=CC=C(C=C2)C3=NC(OC[C@H]4CNCCO4)=C5C=NNC5=N3)=O)=C1)F.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
308-R hydrochloride Related Classifications
HY-44291 Related Classifications
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