country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-153269

Copy Link Print Information

9-Methyl-SMN-C5

9-Methyl-SMN-C5 is a SMN2 pre-mRNA splicing modifier that corrects exon 7 splicing. 9-Methyl-SMN-C5 binds to ESE2 and the 5'-splice site of exon 7, and stabilizes the RNP complex. 9-Methyl-SMN-C5 induces chemical shift perturbations at the 5'-splice site of the exon 7-U1 snRNA duplex. 9-Methyl-SMN-C5 partially blocks the binding of hnRNP G to ESE2. 9-Methyl-SMN-C5 can be used for research on spinal muscular atrophy (SMA).

For research use only. We do not sell to patients.

CAS No.: 2248691-80-5
Formula: C₂₂H₂₃FN₆O
Molecular Weight:406.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

9-Methyl-SMN-C5 Chemical Structure

CAS No.: 2248691-80-5

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

9-Methyl-SMN-C5 binds the 5′-ss exon 7-U1 snRNA duplex as well as the ESE2 fragment of SMN2 pre-mRNA, with the 5′-ss interaction being more important than ESE2^[1].
9-Methyl-SMN-C5 corrects exon 7 splicing of SMN2 pre-mRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS No. 2248691-80-5
Molecular Weight 406.47
Formula C₂₂H₂₃FN₆O
SMILES

O=C1C=C(N=C2C(=CC(=CN12)N3CCN(C)CC3)C)C=4C=C(F)C5=NC(=CN5C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proceedings of the National Academy of Sciences of the United States of America. 2018 May 15;115(20):E4604-E4612. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote