2248691-80-5
Chemical Structure
9-Methyl-SMN-C5
- CAS No.: 2248691-80-5
- Formula:C22H23FN6O
- Molecular Weight:406.47
IUPAC Name: 2-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-9-methyl-7-(4-methylpiperazin-1-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
InChIKey: XWIHRUXFWFHTHC-UHFFFAOYSA-N
SMILES: O=C1C=C(N=C2C(=CC(=CN12)N3CCN(C)CC3)C)C=4C=C(F)C5=NC(=CN5C4)C
Biological Activity: 9-Methyl-SMN-C5 is a SMN2 pre-mRNA splicing modifier that corrects exon 7 splicing. 9-Methyl-SMN-C5 binds to ESE2 and the 5'-splice site of exon 7, and stabilizes the RNP complex. 9-Methyl-SMN-C5 induces chemical shift perturbations at the 5'-splice site of the exon 7-U1 snRNA duplex. 9-Methyl-SMN-C5 partially blocks the binding of hnRNP G to ESE2. 9-Methyl-SMN-C5 can be used for research on spinal muscular atrophy (SMA)[1].
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9-Methyl-SMN-C5 | 9-Methyl-SMN-C5 is a SMN2 pre-mRNA splicing modifier that corrects exon 7 splicing. 9-Methyl-SMN-C5 binds to ESE2 and the 5'-splice site of exon 7, and stabilizes the RNP complex. 9-Methyl-SMN-C5 induces chemical shift perturbations at the 5'-splice site of the exon 7-U1 snRNA duplex. 9-Methyl-SMN-C5 partially blocks the binding of hnRNP G to ESE2. 9-Methyl-SMN-C5 can be used for research on spinal muscular atrophy (SMA). | |||||||||||||||||||||
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