Scoparia dulcis L Extract

Hymenoxin (compound 7) is a dual inhibitor of iNOS and NF-κB with IC₅₀ of 42.7 μM and 85.5 μM respectively. Hymenoxin can inhibit 16% of oxidative stress at a concentration of 125 μg/mL.

Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers.

1-Hydroxy-3,4,5-trimethoxyxanthone is a natural product that can be found in Rubia cordifolia?L..

2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one is a Alkaloids product that can be isolated from the roots of Scoparia dulcis.

Scoparinol (Scopadiol) is a diterpene isolated from Scoparia dulcis that has significant analgesic and anti-inflammatory activities.