PAK Degrader
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JH-XIII-05-01
0 ImagesCat. No.: HY-133616CAS No.: 2374699-35-9JH-XIII-05-01 is a cereblon-recruiting PROTAC degrader targeting IRAK1 and IRAK4, with DC50 values of 0.065 μM and 3.63 μM, respectively (TMD8 cells). JH-XIII-05-01 reduces cancer cell viability, induces apoptosis in primary MYD88-mutant WM cells and MYD88-mutant/wild-type lymphoma cells, and selectively degrades additional cereblon neosubstrates and kinases IKZF1, IKZF3, CSNK1A1, CSNK1D, CSNK1E, and PAK4. JH-XIII-05-01 can be used for research on Waldenström macroglobulinemia, diffuse large B-cell lymphoma, and B-cell lymphoma.
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CPS-021
0 ImagesCat. No.: HY-174247CPS-021 is a selective PAK4 PROTAC degrader with a DC50 of 50 nM. CPS-021 degrades PAK4 via the ubiquitin-proteasome system. CPS-021 inhibits the migration and invasion of tumor cells, suppresses TGFβ-induced epithelial-mesenchymal transition (EMT) in tumor cells, and can be used in studies related to lung cancer metastasis.
