FASTK Activator
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Casuarinin
0 ImagesCasuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections.
