Acetyl-pepstatin ammonium
Based on 1 Customer Validation
Acetyl-pepstatin ammonium is an aspartic protease (PRs) inhibitor that targets HIV-1 protease and XMRV protease with Ki values of 13 nM and 712 nM, respectively. Acetyl-pepstatin ammonium inhibits XMRV protease by blocking cleavage through mixed-mode binding. Acetyl-pepstatin ammonium can be used in research related to HIV-1 and XMRV infection.
For research use only. We do not sell to patients.
- Formula: C31H60N6O9
- Molecular Weight:660.84
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIV-1 13 nM (Ki, HIV-1 protease) |
XMRV protease 712 nM (Ki) |
In Vitro
Acetyl-pepstatin (3.0 μM; 1 h) ammonium produces 50% inhibition of XMRV PR-mediated cleavage of recombinant MLV Gag fragments in SDS-PAGE experiments[1].
Acetyl-pepstatin ammonium binds XMRV PR in a mixed mode, involving two half-occupied head-to-head molecules and one half-occupied standard-mode molecule, as determined by the 2.0 Å crystal structure PDB 4EXH[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 660.84
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Formula C31H60N6O9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 20 mg/mL (30.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5132 mL | 7.5661 mL | 15.1323 mL | 37.8306 mL |
| 5 mM | 0.3026 mL | 1.5132 mL | 3.0265 mL | 7.5661 mL | |
| 10 mM | 0.1513 mL | 0.7566 mL | 1.5132 mL | 3.7831 mL | |
| 15 mM | 0.1009 mL | 0.5044 mL | 1.0088 mL | 2.5220 mL | |
| 20 mM | 0.0757 mL | 0.3783 mL | 0.7566 mL | 1.8915 mL | |
| 25 mM | 0.0605 mL | 0.3026 mL | 0.6053 mL | 1.5132 mL | |
| 30 mM | 0.0504 mL | 0.2522 mL | 0.5044 mL | 1.2610 mL |
Acetyl-pepstatin ammonium Related Classifications
HY-P1436A Related Classifications
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