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Cat. No.: HY-186338

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ALK-IN-39

ALK-IN-39 is an ALK inhibitor. ALK-IN-39 targets anaplastic lymphoma kinase fusion proteins and inhibits NPM-ALK-dependent proliferation. ALK-IN-39 inhibits the proliferation of cells expressing Tel-InsR as well as wild-type hematopoietic cells and anaplastic large cell lymphoma cells. ALK-IN-39 can be used in research on anaplastic large cell lymphoma (ALCL).

For research use only. We do not sell to patients.

CAS No.: 845812-90-0
Formula: C₃₂H₄₄ClN₇O₃S
Molecular Weight:642.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ALK-IN-39 Chemical Structure

CAS No.: 845812-90-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Anti-cancer

ALK-IN-39 (Compound 17e) inhibits Ba/F3-NPM-ALK and Karpas299 cell proliferation with IC₅₀ values of 258.4 and 100.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 845812-90-0
Molecular Weight 642.25
Formula C₃₂H₄₄ClN₇O₃S
SMILES

O=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC(C)C)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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