845812-90-0
845812-90-0
Chemical Structure
ALK-IN-39
- CAS No.: 845812-90-0
- Formula:C32H44ClN7O3S
- Molecular Weight:642.25
InChIKey: PIBITIKJRIGPID-UHFFFAOYSA-N
SMILES: O=S(C1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC(C)C)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Biological Activity: ALK-IN-39 is an ALK inhibitor. ALK-IN-39 targets anaplastic lymphoma kinase fusion proteins and inhibits NPM-ALK-dependent proliferation. ALK-IN-39 inhibits the proliferation of cells expressing Tel-InsR as well as wild-type hematopoietic cells and anaplastic large cell lymphoma cells. ALK-IN-39 can be used in research on anaplastic large cell lymphoma (ALCL)[1].
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ALK-IN-39 | ALK-IN-39 is an ALK inhibitor. ALK-IN-39 targets anaplastic lymphoma kinase fusion proteins and inhibits NPM-ALK-dependent proliferation. ALK-IN-39 inhibits the proliferation of cells expressing Tel-InsR as well as wild-type hematopoietic cells and anaplastic large cell lymphoma cells. ALK-IN-39 can be used in research on anaplastic large cell lymphoma (ALCL). | |||||||||||||||||||||
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References
- [1]. Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90. [Content Brief]
