Aminophylline dihydrate

Aminophylline (5-20 mg/kg; i.p.; once daily for 15 consecutive days) Dihydrate exerts dose-dependent antidepressant activity in mice with chronic restraint stress-induced depressive-like behaviors. It significantly reduces the immobility time of mice in the tail suspension test and forced swimming test, and increases their grooming time in the sucrose splash test^[1].
Aminophylline (50-100 mg/kg; i.p.; single administration; treatment 30 min prior to electroshock test) Dihydrate potently reduces the anti-electroconvulsive efficacy of most tested antiepileptic drugs in mice^[2].
Aminophylline (7 mg/kg loading dose + 1.5 mg/kg/hr maintenance dose; i.v.; single continuous infusion; duration ≥ 1.5 h) Dihydrate increases minute ventilation, tidal volume, respiratory rate, parasternal muscle shortening, minute integrated electromyographic activity of the parasternal muscle, and parasternal muscle contractility in awake healthy dogs, while it does not alter tidal electromyographic activity and baseline muscle length of the parasternal muscle^[6].