Anti-MRSA agent 46

Anti-MRSA agent 46 (compound 5D) (16-20 h) inhibits S. aureus ATCC 29213, MRSA N315, and MRSA isolates with MIC of 0.5-1 μg/mL^[1].
Anti-MRSA agent 46 (1-8× MIC; 0-8 h) rapidly kills MRSA N315 in both the early and late growth phases^[1].
Anti-MRSA agent 46 shows a low propensity for resistance development, with the MIC against MRSA remaining at 1 μg/mL after 20 passages^[1].
Anti-MRSA agent 46 (0-6 h) retains anti-MRSA activity after plasma exposure, with an MIC of 2 μg/mL and an MBC of 16 μg/mL^[1].
Anti-MRSA agent 46 (1-64 μg/mL; 16-18 h) effectively disrupts preformed MRSA N315 biofilms^[1].
Anti-MRSA agent 46 (8 μg/mL; 4 h) disrupts the bacterial envelope morphology of MRSA N315, causing surface collapse and membrane rupture^[1].
Anti-MRSA agent 46 (8-32 μg/mL; 0-30 min) dissipates the membrane potential of MRSA N315 in a concentration-dependent manner^[1].
Anti-MRSA agent 46 (8-32 μg/mL; 0-30 min) increases MRSA N315 membrane permeability in a time- and concentration-dependent manner^[1].
Anti-MRSA agent 46 (8× MIC; 4 h) impairs MRSA N315 membrane integrity, as evidenced by increased PI-positive staining^[1].
Anti-MRSA agent 46 (1-8 μg/mL; 4 h) causes leakage of proteins and DNA from MRSA N315^[1].
Anti-MRSA agent 46 (1 h) shows no significant hemolytic activity against MRSA N315 at 32× MIC^[1].

Anti-MRSA agent 46 (1-4× MIC; 1-3 h) significantly perturbs glycerophospholipid metabolism in MRSA N315, reducing CDP-DG and downstream PG/PS/PE species while increasing PA species^[1].
Anti-MRSA agent 46 (24 h) shows attenuated antibacterial activity in the presence of PG and PE, supporting its preferential interaction with membrane phospholipids^[1].

Anti-MRSA agent 46 (1-8× MIC; 4 h) depletes intracellular ATP in MRSA N315^[1].

Anti-MRSA agent 46 (1-8× MIC; 1.5 h) induces ROS accumulation in MRSA N315^[1].

Anti-MRSA agent 46 (2-64 μg/mL; 24 h) shows moderate cytotoxicity against NIH/3T3 and RAW 264.7 cells, with IC50 values of 26.21 and 17.93 μg/mL, respectively^[1].

Anti-MRSA agent 46 can directly bind phosphatidylglycerol with a K_d of 1.22 μM^[1].