2883235-38-7
Chemical Structure
Anti-MRSA agent 46
- CAS No.: 2883235-38-7
- Formula:C40H64Br2N4O4
- Molecular Weight:824.77
InChIKey: RLNIBIUAFDDWJD-UHFFFAOYSA-N
SMILES: CCCCCNC(C[N+](C)(C)CCOC1=CC=C(C2=C(OCC[N+](C)(C)CC(NCCCCC)=O)C=CC(CC=C)=C2)C=C1CC=C)=O.[Br-].[Br-]
Biological Activity: Anti-MRSA agent 46 is a Methicillin-resistant Staphylococcus aureus (MRSA) membrane-disrupting agent. Anti-MRSA agent 46 disrupts bacterial membrane integrity and morphology, dissipates membrane potential, increases membrane permeability, and perturbs glycerophospholipid metabolism. Anti-MRSA agent 46 induces intracellular DNA and protein leakage, reduces intracellular ATP levels, and induces reactive oxygen species (ROS) production. Anti-MRSA agent 46 disrupts MRSA biofilms, reduces bacterial burden, exhibits a low propensity for resistance, and retains antibacterial activity after plasma exposure, and improves survival in a mouse sepsis infection model. Anti-MRSA agent 46 can be used for research related to MRSA infection[1].
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Anti-MRSA agent 46 | Anti-MRSA agent 46 is a Methicillin-resistant Staphylococcus aureus (MRSA) membrane-disrupting agent. Anti-MRSA agent 46 disrupts bacterial membrane integrity and morphology, dissipates membrane potential, increases membrane permeability, and perturbs glycerophospholipid metabolism. Anti-MRSA agent 46 induces intracellular DNA and protein leakage, reduces intracellular ATP levels, and induces reactive oxygen species (ROS) production. Anti-MRSA agent 46 disrupts MRSA biofilms, reduces bacterial burden, exhibits a low propensity for resistance, and retains antibacterial activity after plasma exposure, and improves survival in a mouse sepsis infection model. Anti-MRSA agent 46 can be used for research related to MRSA infection. | |||||||||||||||||||||
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