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Cat. No.: HY-187106

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Antibacterial agent 361

Antibacterial agent 361 is an antibacterial agent as well as a membrane-permeable prodrug. Antibacterial agent 361 binds to subsite I of the linear motif binding pocket of the Escherichia coli sliding clamp, disrupts the interaction between the sliding clamp and its chaperone protein, and inhibits sliding clamp-dependent in vitro DNA replication. Antibacterial agent 361 can be used in the research of bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 874968-47-5
Formula: C₁₅H₁₆ClNO₂
Molecular Weight:277.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 361 Chemical Structure

CAS No.: 874968-47-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Biological Activity

Description

In Vitro

OthersBacterial Infection

Others

Antibacterial agent 361 (compound 10) inhibits the interaction between the Escherichia coli sliding clamp and the consensus linear motif peptide, with a K_i of approximately 499 μM and an IC₅₀ of approximately 899 μM^[1].
Antibacterial agent 361 is a prodrug of compound 8^[1].

Bacterial Infection

Antibacterial agent 361 (24 h) inhibits the growth of E. coli DH5α, B. subtilis SU5 and S. aureus NCTC8325 with an MIC of 22 μg/mL; it exhibits an MIC of 43 μg/mL against A. baylyi ADP1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 874968-47-5
Molecular Weight 277.75
Formula C₁₅H₁₆ClNO₂
SMILES

O=C(OCC)C1CC=2C=3C=C(Cl)C=CC3NC2CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yin Z, et al. Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. Journal of medicinal chemistry. 2014 Mar 27;57(6):2799-806. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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