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Cat. No.: HY-187437

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CYP51-IN-33

CYP51-IN-33 is a CYP51 inhibitor with an IC₅₀ of 0.35 μM against the sterol 14α-demethylase activity of Rhizoctonia solani CYP51. CYP51-IN-33 interferes with CYP51-associated ergosterol biosynthesis, accompanied by changes in hyphal morphology, increased membrane permeability and intracellular ROS accumulation. CYP51-IN-33 can be used in studies on CYP51-targeted antifungal activity and rice sheath blight.

For research use only. We do not sell to patients.

CAS No.: 3133348-60-1
Formula: C₁₄H₁₂Cl₂N₄OS
Molecular Weight:355.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CYP51-IN-33 Chemical Structure

CAS No.: 3133348-60-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CYP51

0.35 μM (IC₅₀)

All Cytochrome P450 Isoforms :

In Vitro

Fungal InfectionOxidative StressCarbohydrate MetabolismLipid MetabolismOthersAnti-cancer

Fungal Infection

CYP51-IN-33 (Compound F50) at 20 mg/L potently inhibits mycelial growth of Valsa mali, Sclerotinia sclerotiorum, Botrytis cinerea, Rhizoctonia solani, Alternaria alternata, Fusarium graminearum, Curvularia lunata, and Phytophthora capsici in vitro, with EC₅₀ values ranging from 0.01 to 0.77 mg/L^[1].
CYP51-IN-33 potently inhibits the CYP51 enzyme activity of Rhizoctonia solani in vitro, with an IC₅₀ value of 0.35 μM^[1].
CYP51-IN-33 (0.1 mg/L; 24 h) alters the transcriptome of Rhizoctonia solani, including the upregulation and downregulation of key genes in the ergosterol biosynthesis pathway^[1].

Fungal Infection

Oxidative Stress

CYP51-IN-33 (0.1 mg/L) alters the mycelial morphology of Rhizoctonia solani, increases cell membrane permeability, and induces intracellular ROS accumulation^[1].

Fungal Infection

Carbohydrate Metabolism

Lipid Metabolism

CYP51-IN-33 (0.1 mg/L) alters the metabolome of Rhizoctonia solani, causing dysregulation of membrane-related metabolic pathways, carbohydrate metabolic pathways, and cofactor metabolic pathways^[1].

Others

CYP51-IN-33 at concentrations of 1.0-2.0 mg/L exerts only a slight effect on HepG2 cell viability even at the highest concentration of 2.0 mg/L^[1].

Anti-cancer

CYP51-IN-33 (1.0 or 2.0 mg/L) exerts minimal effects on the viability of HepG2 cells, with the proportions of viable cells reaching 94.24% and 93.83%, respectively, compared with 94.30% in the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CYP51-IN-33 (Compound F50) (10-20 mg/kg; p.o.; daily; 7 days) shows no obvious mammalian toxicity in female mice following 7 days of oral administration at doses of 10 mg/kg/day and 20 mg/kg/day^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female mice^[1]
Dosage:

10 mg/kg; 20 mg/kg
Administration:

p.o.; daily; 7 days
Result:

Caused no mortality or obvious abnormal clinical signs.
Showed no evident treatment-related lesions in histological examination of the heart, liver, spleen, lungs, and kidneys.
Maintained largely comparable relative weights of the heart, kidneys, spleen, and lungs to controls, with only a slight increase in relative liver weight.
Maintained body weight throughout the observation period.

Related Protocols :

Chemical Information

CAS No. 3133348-60-1
Molecular Weight 355.24
Formula C₁₄H₁₂Cl₂N₄OS
SMILES

OC(C1=NC=C(C)S1)(C2=CC=C(Cl)C=C2Cl)CN3N=CN=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cheng X, et al. De Novo Discovery of Ecofriendly Antifungal Agents Using Generative AI and Hierarchical Virtual Screening. Journal of agricultural and food chemistry. 2026 Aug 05;74(30):23883-23899.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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CYP51-IN-33

All Cytochrome P450 Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CYP51-IN-33 Related Classifications

HY-187437 Related Classifications

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