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Cat. No.: HY-189568

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Laccase-IN-7

Laccase-IN-7 is a laccase inhibitor (IC₅₀ 0.064 mM). Laccase-IN-7 disrupts fungal redox homeostasis, leading to oxidative damage. Laccase-IN-7 induces intracellular ROS accumulation, fungal cell membrane damage, apoptosis-like programmed cell death, and disruption of mycelial morphology and ultrastructure. Laccase-IN-7 exhibits broad-spectrum fungicidal activity against plant pathogenic fungi and inhibits sclerotial germination of S. rolfsii. Laccase-IN-7 has protective efficacy against peanut stem rot. Laccase-IN-7 can be used for research on peanut stem rot.

For research use only. We do not sell to patients.

CAS No.: 16913-61-4
Formula: C₉H₁₀ClNS₂
Molecular Weight:231.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Laccase-IN-7 Chemical Structure

CAS No.: 16913-61-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Fungal InfectionOthers

Fungal Infection

Antifungal agent 185 (Compound b6) exhibits potent antifungal activity against S. rolfsii, with an EC₅₀ of 0.75 mg/L, and shows broad-spectrum inhibitory effects against other plant pathogenic fungi^[1].
Antifungal agent 185 (0-20 mg/L; 72 h) completely inhibits sclerotial germination of S. rolfsii at concentrations ≥5 mg/L, disrupts mycelial morphology and cellular ultrastructure, and induces membrane damage and intracellular ROS accumulation in hyphae^[1].
Antifungal agent 185 (5 mg/L; 8 h) significantly alters the transcriptome of S. rolfsii, including upregulating SS1G-05112 and downregulating SS1G-00974^[1].
Antifungal agent 185 (100-200 mg/L; 7 days after inoculation) exhibits high protective efficacy against S. rolfsii on peanut seedlings, with a protective efficacy of 84.66% at 200 mg/L^[1].

Others

Antifungal agent 185 (50-200 mg/L; 170 h) does not reduce the germination rate of peanut seeds, but inhibits radicle length in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 16913-61-4
Molecular Weight 231.77
Formula C₉H₁₀ClNS₂
SMILES

ClC1=CC=C(SC(N(C)C)=S)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li R, et al. Discovery of Thiram-Inspired Thiocarbamate Derivatives as Novel Laccase Inhibitors against Sclerotium rolfsii. Journal of Agricultural and Food Chemistry.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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