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Cat. No.: HY-189804

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Antifungal agent 188

Antifungal agent 188 is an Antifungal agent. Antifungal agent 188 exhibits weak inhibitory activity against E. coli PDHc-E1, with IC₅₀ = 59.7 μM. Antifungal agent 188 induces extensive ultrastructural damage in fungal hyphae, disrupting the cell wall and cell membrane. Antifungal agent 188 causes mitochondrial dysfunction and impaired energy production. Antifungal agent 188 induces ROS accumulation. Antifungal agent 188 interferes with glucan-related carbohydrate processes, reduces β-glucan (HY-W145521) content, and impairs cell wall integrity. Antifungal agent 188 is a potent in vitro inhibitor of M. fructicola and B. cinerea. Antifungal agent 188 can be used for research on peach brown rot.

For research use only. We do not sell to patients.

CAS No.: 2951082-10-1
Formula: C₁₂H₁₁F₃N₆O
Molecular Weight:312.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antifungal agent 188 Chemical Structure

CAS No.: 2951082-10-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
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Biological Activity

Description

In Vitro

Fungal InfectionBacterial InfectionMitochondrial FunctionOxidative Stress

Fungal Infection

Antifungal agent 188 (Compound 4b-8) (3-5 days) is a potent in vitro inhibitor of M. fructicola and B. cinerea, with EC₅₀ values of 0.3 and 0.7 μg/mL, respectively, and shows lower activity against other tested fungi/oomycetes^[1].
Antifungal agent 188 (50-125 μg/mL; 12 h before inoculation; 4-5 days after inoculation) effectively controls peach brown rot caused by M. fructicola, with control efficacy reaching 93-100% at 50-125 μg/mL^[1].
Antifungal agent 188 (0.3-2 μg/mL; 72 h) reduces cellular β-1,3-glucan content in M. fructicola, supporting its interference with glucan-related cell wall processes^[1].

Bacterial Infection

Antifungal agent 188 (100 μM) exhibits weak inhibitory activity against E. coli PDHc-E1, with IC₅₀ = 59.7 μM, indicating that its antifungal activity is independent of PDHc-E1^[1].

Fungal Infection

Mitochondrial Function

Antifungal agent 188 (0.3-2.0 μg/mL; 72 h) impairs mitochondrial function in M. fructicola hyphae, causing dose-dependent ATP depletion and MMP dissipation^[1].

Fungal Infection

Oxidative Stress

Antifungal agent 188 (0.3-2.0 μg/mL; 72 h) induces ROS accumulation in M. fructicola, especially at 0.3 μg/mL, consistent with oxidative stress and mitochondrial damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antifungal agent 188 (0.1-10 μg/mL; 24-96 h) exhibits moderate acute toxicity to zebrafish^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2951082-10-1
Molecular Weight 312.25
Formula C₁₂H₁₁F₃N₆O
SMILES

NC1=C(/C=N/NC2=CC=C(OC(F)(F)F)C=C2)C(N)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zeng L, et al. Discovery and Mechanistic Investigation of Aminopyrimidine/Pyridine Hydrazone 4b-8 as a Potent Fungicide Candidate with Distinct Glucan-Associated Antifungal Mechanisms. J Agric Food Chem. 2026 Sep 9;74(35):27967-27977.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Antifungal agent 188