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Cat. No.: HY-P12210

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Antimicrobial peptide BP100

Antimicrobial peptide BP100 is a linear undecapeptide with an amphipathic α-helical structure that exhibits antibacterial activity. Antimicrobial peptide BP100 shows in vitro antibacterial activity against a variety of plant and human pathogens. Antimicrobial peptide BP100 binds to and inserts into bacterial cell membranes through electrostatic attraction, triggering membrane permeabilization and ultimately leading to membrane disruption. Antimicrobial peptide BP100 can be used for research on bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1001644-68-3
Formula: C₇₂H₁₂₅N₁₇O₁₂
Molecular Weight:1420.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimicrobial peptide BP100 Chemical Structure

CAS No.: 1001644-68-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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References
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Biological Activity

Description

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Antimicrobial peptide BP100 exhibits antibacterial activity against a variety of clinically relevant human pathogens, with MIC values ranging from 8.5 to 134.5 μg/mL^[2].
Antimicrobial peptide BP100 (0.3-8 μM; 0.5-5 h) disrupts the cell envelope, causes membrane surface blebbing and collapse, and induces leakage of intracellular contents in E. coli (ATCC 25922) cells^[4].
Antimicrobial peptide BP100 (0.5-8 μM; 15 min) neutralizes the negative charge on the membrane surface and alters the Zeta potential in E. coli cells, with the concentration for complete neutralization being approximately 2-4 µM^[4].
Antimicrobial peptide BP100 (0.8-50 μM; 48 h) exhibits antibacterial activity by inhibiting bacterial growth in plant pathogenic cells such as E. amylovora and P. syringae^[5].

Others

Antimicrobial peptide BP100 exhibits extremely low induction of hemolysis in horse erythrocytes and human erythrocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1001644-68-3
Molecular Weight 1420.87
Formula C₇₂H₁₂₅N₁₇O₁₂
SMILES

OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CC(C)C)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](N)CCCCN)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O
Sequence

Lys-Lys-Leu-Phe-Lys-Lys-Ile-Leu-Lys-Tyr-Leu-NH2
Sequence Shortening

KKLFKKILKYL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Riesco-Llach G, et al. Deciphering the Mechanism of Action of the Antimicrobial Peptide BP100. International journal of molecular sciences. 2024 Mar 19;25(6):3456.

[2]. Oddo A, et al. An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action. Antimicrobial agents and chemotherapy. 2016 Jan;60(1):592-9.

[3]. Oliveras À, et al. Peptide Conjugates Derived from flg15, Pep13, and PIP1 That Are Active against Plant-Pathogenic Bacteria and Trigger Plant Defense Responses. Applied and environmental microbiology. 2022 Jun 28;88(12):e0057422.

[4]. Alves CS, et al. Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR. The Journal of biological chemistry. 2010 Sep 03;285(36):27536-44.

[5]. Nadal A, et al. Constitutive expression of transgenes encoding derivatives of the synthetic antimicrobial peptide BP100: impact on rice host plant fitness. BMC plant biology. 2012 Sep 04;12:159.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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