Antiviral agent-89
Antiviral agent-89 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral agent-89 exhibits broad-spectrum anti-HIV-1 activity against wild-type and NNRTI-resistant strains, and shows selectivity and low cytotoxicity in T cells. Antiviral agent-89 can be used for research on HIV-1 infection.
For research use only. We do not sell to patients.
- Formula: C20H18Cl2N2O2S2
- Molecular Weight:453.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | EC50 |
0.002 μM
|
Antiviral activity against wild-type HIV-1 strain NL4-3 in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against wild-type HIV-1 strain NL4-3 in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
|
acsomega.6c08020 |
| MT4 | EC50 |
0.004 μM
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Antiviral activity against mutant HIV-1 strain IRLL98 in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against mutant HIV-1 strain IRLL98 in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
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acsomega.6c08020 |
| MT4 | EC50 |
0.32 μM
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Antiviral activity against mutant HIV-1 strain Y181C in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against mutant HIV-1 strain Y181C in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
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acsomega.6c08020 |
| MT4 | EC50 |
0.85 μM
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Antiviral activity against mutant HIV-1 strain Y188L in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against mutant HIV-1 strain Y188L in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
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acsomega.6c08020 |
| MT4 | EC50 |
0.008 μM
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Antiviral activity against mutant HIV-1 strain K103N in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against mutant HIV-1 strain K103N in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
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acsomega.6c08020 |
| MT4 | EC50 |
0.042 μM
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Antiviral activity against mutant HIV-1 strain K103N+Y181C in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
Antiviral activity against mutant HIV-1 strain K103N+Y181C in MT-4 cells assessed as EC50 by MTT viability assay after 5 days postinfection.
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acsomega.6c08020 |
| MT4 | CC50 |
55 μM
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Cytotoxicity against MT-4 cells assessed as CC50 greater than 55 μM by MTT viability assay after 5 days.
Cytotoxicity against MT-4 cells assessed as CC50 greater than 55 μM by MTT viability assay after 5 days.
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acsomega.6c08020 |
In Vitro
Antiviral agent-89 (incubated at 37°C for 20 minutes) inhibits recombinant WT HIV-1 RT with an ID50 of 5 nM and retains activity against the K103N, Y181I, and L100I mutant RTs[1].
Antiviral agent-89 (5.85-8.30 pID50) inhibits WT HIV-1 RT with a pID50 of 8.30[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 453.41
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Formula C20H18Cl2N2O2S2
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SMILES
COC1=CC=C(SCSC(N2)=NC(CC3=C(Cl)C=CC=C3Cl)=C(C)C2=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiviral agent-89 Related Classifications
HY-189946 Related Classifications
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