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Cat. No.: HY-115821

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Ascorutin

Name: Ascorutin
Brand: MedChemExpress
SKU: HY-115821
Availability: PreOrder

(Synonyms: Rutascorbin)

Ascorutin (Rutascorbin) is an orally effective antioxidant and anti-inflammatory agent composed of a combination of ascorbic acid and rutin. Ascorutin, based on the synergistic action of ascorbic acid and rutin, comprehensively enhances and regulates local and systemic immune function by reducing oxidative stress, modulating calcium-phosphorus metabolism, and inhibiting the release of inflammatory mediators. Ascorutin can be used in the study of periodontitis.

For research use only. We do not sell to patients.

CAS No.: 8067-12-7
Formula: C₃₃H₃₈O₂₂
Molecular Weight:786.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (293 KB)

Ascorutin Chemical Structure

CAS No.: 8067-12-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Oxidative Stress

Ascorutin (Rutascorbin) exhibits antioxidant activity as a reference standard in the antioxidant assay system, with an AOA value of 51.10 mmol-equiv./m_{dry res.}^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adaptive ImmunityOthers

Adaptive Immunity

Ascorutin (Rutascorbin) (0.25 mg/kg, as part of the TPC; i.g.; once daily; 21 days) reduces leukocyte levels and increases serum IgG, IgA, and IgM concentrations in rats with experimental gingivitis under conditions of heavy metal and iodine/fluorine deficiency^[4].

Others

Ascorutin (12.4 mg/kg; i.g.; 15 days) restores calcium and phosphorus concentrations in serum and periodontal tissue homogenates of male white rats with experimental periodontitis^[1].
Ascorutin (12.4 mg/kg; 15 days) reduces serum ceruloplasmin activity in rats with experimental periodontitis, decreasing to 382.30 mg/L by day 15^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

white rats (average weight 54 g)^[4]
Dosage:

0.25 mg/kg, as part of the TPC
Administration:

i.g.; once daily; 21 days
Result:

Improved the immune and metabolic status of the animals.
- The peripheral blood leukocyte count of the experimental animals significantly decreased by 44.23%.
Increased, with IgG increasing by 7.30%, IgA by 19.45%, and IgM by 17.67%, effectively restoring the body's immune defense capabilities.

Related Protocols :

Chemical Information

CAS No. 8067-12-7
Molecular Weight 786.64
Formula C₃₃H₃₈O₂₂
SMILES

OC[C@@H]([C@]1([H])C(O)=C(C(O1)=O)O)O.O=C(C(O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)=C(C4=CC(O)=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
Synonyms

Rutascorbin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shanaida YV, et al. Changes in the concentrations of calcium and phosphorus during modeling of periodontal tissue disease and its correction. Ukrainian Dental Almanac. 2025 Dec 31(4):24-37.

[2]. Шанайда ЮВ, et al. Study of ceruloplasmin activity in experimental periodontitis and after its correction. Харківський стоматологічний журнал. 2025 Dec 30;2(4 (6)):606-17.

[3]. Maslov O, et al. Investigation the influence of biologically active compounds on the antioxidant, antibacterial and anti-inflammatory activities of red raspberry (Rubus idaeus L.) leaf extract. Curr Issues Pharm Med Sci. 2022;35(4):229-35.

[4]. Malko NV, et al. Estimation of influence of the therapeutic–prophylactic complex on the immune system indices of experimental animals with simulated gingivitis. Ukrainian Dental Almanac. 2018 Jun 25(2):9-12.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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