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Cat. No.: HY-190158

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AZ-007

AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers.

For research use only. We do not sell to patients.

CAS No.: 2488429-19-0
Formula: C₁₄H₁₂N₄S
Molecular Weight:268.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-007 Chemical Structure

CAS No.: 2488429-19-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

AZ-007 binds to the 14-3-3σ/p53^pT387 interface in X-ray crystallography (PDB 6RWH) and produces no additional electron density in 14-3-3σ/TAZ^pS89 crystals, supporting selective targeting of the p53-bound interface over the TAZ-bound interface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2488429-19-0
Molecular Weight 268.34
Formula C₁₄H₁₂N₄S
SMILES

N=C(N)C1=CC(C2=CC=CC=C2)=C(C3=CN=CN3)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guillory X, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry. 2020 Jul 09;63(13):6694-6707.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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