2488429-19-0
2488429-19-0
Chemical Structure
AZ-007
- CAS No.: 2488429-19-0
- Formula:C14H12N4S
- Molecular Weight:268.34
InChIKey: FXABOLLAJZFHEL-UHFFFAOYSA-N
SMILES: N=C(N)C1=CC(C2=CC=CC=C2)=C(C3=CN=CN3)S1
Biological Activity: AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers[1].
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AZ-007 | AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers. | |||||||||||||||||||||
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