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Cat. No.: HY-P5910A

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Azurin p28 peptide TFA

Azurin p28 peptide TFA is a cell-penetrating peptide derived from the copper-containing oxidoreductase azurin of Pseudomonas aeruginosa, possessing antitumor and anti-angiogenic activities. Azurin p28 peptide TFA can selectively enter tumor cells as a cell-penetrating peptide, block the interaction between COP1 and p53, inhibit p53 degradation, and elevate intracellular p53 protein levels. Azurin p28 peptide TFA can induce tumor cell apoptosis. Azurin p28 peptide TFA can be used in cancer-related research, such as breast cancer and central nervous system tumors.

For research use only. We do not sell to patients.

Formula: C₁₂₂H₁₉₇N₃₁O₄₇S₂.xCF₃COOH
Molecular Weight:2914.18(free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azurin p28 peptide TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Anti-cancerLocal Vascular RegulationApoptosisOthers

Anti-cancer

Local Vascular Regulation

Azurin p28 peptide TFA selectively invades and exerts cytotoxic effects on acute and chronic myeloid leukemia cell lines by inducing apoptosis and interfering with angiogenesis in human umbilical vein endothelial cells^[1].

Apoptosis

Azurin p28 peptide (Azurin p28) TFA exerts dose-dependent antiproliferative and pro-apoptotic effects in Raji cells, increasing the apoptosis rate to 25%^[2].

Anti-cancer

Apoptosis

Azurin p28 peptide TFA alone inhibits breast cancer cell viability, with an IC₅₀ of 23 µM in MCF-7 and MDA-MB-231 cells, and induces apoptosis^[2].

Others

The Azurin p28 peptide TFA functions as a cell-penetrating peptide and preferentially accumulates inside tumor cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Azurin p28 peptide TFA exhibits significant antitumor activity against MCF-7 xenografts in nude mice and inhibits the growth of HCT-116, UISO-Mel-23, and MDA-MB-231 xenografts in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 2914.18(free base)
Formula C₁₂₂H₁₉₇N₃₁O₄₇S₂.xCF₃COOH
Sequence

Leu-Ser-Thr-Ala-Ala-Asp-Met-Gln-Gly-Val-Val-Thr-Asp-Gly-Met-Ala-Ser-Gly-Leu-Asp-Lys-Asp-Tyr-Leu-Lys-Pro-Asp-Asp
Sequence Shortening

LSTAADMQGVVTDGMASGLDKDYLKPDD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baindara P, et al. Bacteriocins: perspective for the development of novel anticancer drugs. Applied microbiology and biotechnology. 2018 Dec;102(24):10393-10408.
[Content Brief]

[2]. Goh KS, et al. A comprehensive review on the anticancer potential of bacteriocin: preclinical and clinical studies. International Journal of Peptide Research and Therapeutics. 2022 Mar;28(2):75.

[3]. Zhang H, et al. Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules. Pharmaceutics. 2023 Aug 07;15(8):2093.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Azurin p28 peptide TFA

Biological Activity

Description

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Azurin p28 peptide TFA Related Classifications

HY-P5910A Related Classifications

Bioz

Keywords

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