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Cat. No.: HY-N21782

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Bakkenolide IIa

Bakkenolide IIa is a bakkenolide-type sesquiterpene with antioxidant and neuroprotective activities. It scavenges DPPH (HY-112053) free radicals, inhibits lipid peroxidation, and protects primary cortical neurons from oxygen-glucose deprivation and oxidative damage. Bakkenolide IIa can be used in neuroprotection-related research.

For research use only. We do not sell to patients.

CAS No.: 915289-59-7
Formula: C₂₅H₃₄O₆
Molecular Weight:430.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bakkenolide IIa Chemical Structure

CAS No.: 915289-59-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Oxidative StressFerroptosis

Oxidative Stress

Bakkenolide IIa (25-100 μg/mL; 1 h pre-incubation, 2 h anoxia, 24 h re-oxygenation) protects primary cultured rat cerebral cortical neurons against oxygen-glucose deprivation-induced injury, increasing cell viability to 73.4% at 100 μg/mL and reducing LDH release in a concentration-dependent manner^[1].
Bakkenolide IIa (25-100 μg/mL; co-incubated during oxidative insult, 24 h recovery) protects primary cultured rat cerebral cortical neurons against multiple oxidative insults, with the highest efficacy against Fe²⁺/ascorbic acid-induced damage, reaching 85.3% cell viability at 100 μg/mL^[1].
Bakkenolide IIa (25-100 μg/mL; 30 min) exhibits concentration-dependent DPPH radical scavenging activity, reaching 80.1% at 100 μg/mL^[1].

Oxidative Stress

Ferroptosis

Bakkenolide IIa (25-100 μg/mL; 1 h) potently inhibits lipid peroxidation in rat forebrain homogenates, with 93.1% inhibition at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 915289-59-7
Molecular Weight 430.54
Formula C₂₅H₃₄O₆
SMILES

O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=C(C)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]

[2]. Quintavalla A, et al. Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies. Current medicinal chemistry. 2018;25(8):917-962.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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