915289-59-7
Chemical Structure
Bakkenolide IIa
- CAS No.: 915289-59-7
- Formula:C25H34O6
- Molecular Weight:430.54
IUPAC Name: (1'R,3R,3a'R,4'S,7'S,7a'R)-3a',4'-dimethyl-4-methylene-2-oxodecahydro-2H-spiro[furan-3,2'-indene]-1',7'-diyl bis(3-methylbut-2-enoate)
InChIKey: DIIABAVIBVSAII-XJCRMMDMSA-N
SMILES: O(C(C=C(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=C(C)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
Biological Activity: Bakkenolide IIa is a bakkenolide-type sesquiterpene with antioxidant and neuroprotective activities. It scavenges DPPH (HY-112053) free radicals, inhibits lipid peroxidation, and protects primary cortical neurons from oxygen-glucose deprivation and oxidative damage. Bakkenolide IIa can be used in neuroprotection-related research[1][2].
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Bakkenolide IIa | Bakkenolide IIa is a bakkenolide-type sesquiterpene with antioxidant and neuroprotective activities. It scavenges DPPH (HY-112053) free radicals, inhibits lipid peroxidation, and protects primary cortical neurons from oxygen-glucose deprivation and oxidative damage. Bakkenolide IIa can be used in neuroprotection-related research. | |||||||||||||||||||||
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References
- [1]. Wang YL, et al. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta medica. 2009 Feb;75(3):230-5. [Content Brief]
- [2]. Quintavalla A, et al. Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies. Current medicinal chemistry. 2018;25(8):917-962.
