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Cat. No.: HY-184512

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BCD38

BCD38 is a selective DHX33 inhibitor with an IC₅₀ of 0.8 μM and a K_d value of 4.7 μM. BCD38 is applicable to lung cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 824961-52-6
Formula: C₂₃H₁₉N₅O
Molecular Weight:381.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BCD38 Chemical Structure

CAS No.: 824961-52-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

BCD38 is a selective DHX33 inhibitor with an IC₅₀ of 0.8 μM and a K_d value of 4.7 μM. BCD38 is applicable to lung cancer-related research^[1]^[2].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U-251	IC₅₀	7.82 μM Compound: BCD38	Antiproliferative activity against human U-251MG cells overexpressing DHX33 assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human U-251MG cells overexpressing DHX33 assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 37838340]

In Vitro

Anti-cancerCell Cycle RegulationEMT / MetastasisOthers

Anti-cancer

Cell Cycle Regulation

Treatment of A549 cells with BCD38 (3-day treatment) induces transcriptomic changes, particularly the downregulation of cell cycle-related genes. These changes are similar to those resulting from DHX33 knockdown, but with weaker potency^[1].

Anti-cancer

Treatment with BCD38 significantly inhibits the anchorage-independent growth of human lung cancer cell lines A549 and H1299 in soft agar assays^[1].

Anti-cancer

EMT / Metastasis

Treatment with BCD38 significantly inhibits the migration of lung cancer cells A549 and H1299^[1].

Others

BCD38 potently and selectively inhibits the helicase activity of wild-type recombinant DHX33 in vitro, with an IC₅₀ of 0.8 μM, while exerting only extremely weak inhibitory effects on other tested RNA helicases^[2].

Others

BCD38 (10 μM) binds directly to recombinant DHX33 protein in vitro, with a K_d value of 4.7 μM^[2].

Anti-cancer

BCD38 (48 h) inhibits the viability of U251-MG cancer cells overexpressing DHX33 in vitro, with an IC₅₀ of 7.82 μM after 48 h of incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

U251-MG DHX33-overexpressing cancer cells
Concentration:

Unclear
Incubation Time:

48 h
Result:

Reduced U251-MG cell viability with an IC₅₀ of 7.82 μM.

Chemical Information

CAS No. 824961-52-6
Molecular Weight 381.43
Formula C₂₃H₁₉N₅O
SMILES

CC1=CC(/C=C(C2=NC3=CC=CC=C3N2)\C#N)=C(N1C4=C(C(C)=C(O4)C)C#N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. DHX33 inhibitors induced transcriptional changes for a subset of genes in cancer cells. Scientific reports. 2026 Jun 05. [Content Brief]

[2]. Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents. Bioorganic & medicinal chemistry letters. 2023 Nov 15;96:129505. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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BCD38

All DNA/RNA Synthesis Isoforms

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BCD38 Related Classifications

HY-184512 Related Classifications

Bioz

Keywords

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