Butaprost free acid (0.5% in methyl acetate)
Based on 2 publication(s) in Google Scholar
Butaprost free acid (0.5% in methyl acetate) is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid (0.5% in methyl acetate) is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid (0.5% in methyl acetate) attenuates fibrosis by hampering TGF-β/Smad2 signalling.
For research use only. We do not sell to patients.
- CAS No.: 215168-33-5
- Formula: C23H38O5
- Molecular Weight:394.54
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Butaprost free acid (0.5% in methyl acetate)
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Biological Activity
Description
In Vitro
Butaprost (1-100 nM; 0.5-24 hours) free acid induces about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells in a dose- and time-dependent. Butaprost free acid upregulated Nur77 gene expression through the PKC pathway[1].
Butaprost (50 μM; 24 hours) free acid reduces TGF-β-induced fibronectin (FN) expression, Smad2 phosphorylation and epithelial-mesenchymal transition in Madin-Darby Canine Kidney (MDCK) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK 293/EBNA cells stably expressing the human EP2 receptor (hEP2-HEK 293/EBNA cells).
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Concentration:1 nM, 10 nM, 100 nM
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Incubation Time:0.5 hours, 1 hours, 6 hours, 24 hours
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Result:Induced about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice (8 weeks of age; 21 g) bearing unilateral ureteral obstruction surgery[2].
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Dosage:1 mg/kg, 2 mg/kg, 4 mg/kg
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Administration:Intraperitoneal injection; twice daily; for 7 days
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Result:Attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery.
Chemical Information
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CAS No. 215168-33-5
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Appearance Liquid
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Molecular Weight 394.54
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Formula C23H38O5
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Color Colorless to light yellow
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SMILES
O=C(O)CCCCCC[C@@H]1[C@@H](/C=C/C[C@@H](O)C2(CCC)CCC2)[C@H](O)CC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders. [Abstract]2024 Nov 28;21(1):307. PMID: 39609821 -
Purity & Documentation
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Data Sheet (290 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142(4):737-48. [Content Brief]
[2]. Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf). 2019 Sep;227(1):e13291. [Content Brief]
[3]. K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2025-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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