215168-33-5
Chemical Structure
Butaprost free acid (0.5% in methyl acetate)
- CAS No.: 215168-33-5
- Formula:C23H38O5
- Molecular Weight:394.54
IUPAC Name: 7-((1R,2R,3R)-3-hydroxy-2-((R,E)-4-hydroxy-4-(1-propylcyclobutyl)but-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid
InChIKey: PAYNQYXOKJDXAV-NMXQQJQMSA-N
SMILES: O=C(O)CCCCCC[C@@H]1[C@@H](/C=C/C[C@@H](O)C2(CCC)CCC2)[C@H](O)CC1=O
Biological Activity: Butaprost free acid (0.5% in methyl acetate) is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid (0.5% in methyl acetate) is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid (0.5% in methyl acetate) attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].
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Butaprost free acid (0.5% in methyl acetate) | Butaprost free acid (0.5% in methyl acetate) is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid (0.5% in methyl acetate) is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid (0.5% in methyl acetate) attenuates fibrosis by hampering TGF-β/Smad2 signalling. | |||||||||||||||||||||
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References
- [1]. Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142(4):737-48. [Content Brief]
- [2]. Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf). 2019 Sep;227(1):e13291. [Content Brief]
- [3]. K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2025-8. [Content Brief]
