c-Met/STAT3-IN-1
c-Met/STAT3-IN-1 is a c-Met/STAT3 inhibitor with IC50 values of 0.79 μM and 0.67 μM, respectively. c-Met/STAT3-IN-1 inhibits the phosphorylation of c-Met receptor tyrosine kinase and STAT3 transcription factor, induces apoptosis, necrotic cell death, and G2/M cell cycle arrest. c-Met/STAT3-IN-1 can be used for research on colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 852231-29-9
- Formula: C22H19FN4S
- Molecular Weight:390.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
c-Met 0.79 μM (IC50) |
STAT3 0.67 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.45 μM
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Cytotoxicity against human HCT-116 colon cancer cells assessed by MTT assay.
Cytotoxicity against human HCT-116 colon cancer cells assessed by MTT assay.
|
42767173 |
| WI-38 | IC50 |
54.48 μM
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Cytotoxicity against normal human WI-38 fibroblasts assessed by MTT assay.
Cytotoxicity against normal human WI-38 fibroblasts assessed by MTT assay.
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42767173 |
In Vitro
c-Met/STAT3-IN-1 shows selective cytotoxicity against HCT-116 colon cancer cells with an IC50 of 2.45 μM and a selectivity index of 22.24 over WI-38 fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Western Blot
- Mammalian live/dead viability and cytotoxicity staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Protocol for Cell Cycle
- Kinase activity and phosphorylation assays
- Nuclear Protein Extraction (High-Salt/Hypotonic Fractionation)
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Cell Cytotoxicity Assay
- Flow cytometric DNA-content cell-cycle staining
- Apoptosis Solutions
- Protocol for Kinase activity and phosphorylation assays
Chemical Information
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CAS No. 852231-29-9
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Molecular Weight 390.48
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Formula C22H19FN4S
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SMILES
FC1=CC=C(C2=CSC3=NC=NC(N4CCN(C5=CC=CC=C5)CC4)=C32)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met/STAT3-IN-1 Related Classifications
HY-189692 Related Classifications
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