1000184-52-0
Chemical Structure
Abz-LVEALYQ-EDDnp
- CAS No.: 1000184-52-0
- Formula:C54H75N13O16
- Molecular Weight:1162.25
InChIKey: CEYQCKOQRKDODN-ZURJUGQSSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCC(N)=O)C(NCCNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC(C3=C(C=CC=C3)N)=O
Biological Activity: Abz-LVEALYQ-EDDnp is a fluorescence resonance energy transfer (FRET) oligopeptide substrate containing a peptide bond that is specifically recognized and cleaved by snake venom metalloproteinases (SVMP). Abz-LVEALYQ-EDDnp is specifically hydrolyzed by SVMP, resulting in the physical separation of the Abz fluorophore and the EDDnp quencher, which relieves the quenching effect and releases a detectable fluorescent signal.. Abz-LVEALYQ-EDDnp is used for research on inflammatory pain and antivenom (Ex/Em = 320-340/420-440 nm)[1][2][3][4][5].
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Abz-LVEALYQ-EDDnp | Abz-LVEALYQ-EDDnp is a fluorescence resonance energy transfer (FRET) oligopeptide substrate containing a peptide bond that is specifically recognized and cleaved by snake venom metalloproteinases (SVMP). Abz-LVEALYQ-EDDnp is specifically hydrolyzed by SVMP, resulting in the physical separation of the Abz fluorophore and the EDDnp quencher, which relieves the quenching effect and releases a detectable fluorescent signal.. Abz-LVEALYQ-EDDnp is used for research on inflammatory pain and antivenom (Ex/Em = 320-340/420-440 nm). | |||||||||||||||||||||
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References
- [1]. de Souza RA, et al. Assessing the Interactions between Snake Venom Metalloproteinases and Hydroxamate Inhibitors Using Kinetic and ITC Assays, Molecular Dynamics Simulations and MM/PBSA-Based Scoring Functions. ACS omega. 2024 Dec 24;9(51):50599-50621.
- [2]. Schneider FS, et al. Identification of protective B-cell epitopes of Atroxlysin-I: A metalloproteinase from Bothrops atrox snake venom. Vaccine. 2016 Mar 29;34(14):1680-7.
- [3]. Kozlova EEG, et al. Computational B-cell epitope identification and production of neutralizing murine antibodies against Atroxlysin-I. Scientific reports. 2018 Oct 08;8(1):14904.
- [4]. Dale CS, et al. The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin. Peptides. 2004 Jan;25(1):81-9.
- [5]. Guerra-Duarte C, et al. Partial in vitro analysis of toxic and antigenic activities of eleven Peruvian pitviper snake venoms. Toxicon : official journal of the International Society on Toxinology. 2015 Dec 15;108:84-96.
