10118-85-1
Chemical Structure
Lydimycin
Synonym(s): α-DHB; α-Dehydrobiotin
- CAS No.: 10118-85-1
- Formula:C10H14N2O3S
- Molecular Weight:242.29
IUPAC Name: (E)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pent-2-enoic acid
InChIKey: NZERRTYPTPRCIR-ARSLAPBQSA-N
SMILES: C(C/C=C/C(O)=O)[C@H]1[C@@]2([C@@](NC(=O)N2)(CS1)[H])[H]
Biological Activity: Lydimycin (α-DHB; α-Dehydrobiotin) is an antibiotic produced by Streptomyces lydicus, with antibacterial, antifungal and antiviral activities. Lydimycin inhibits the binding of SARS-CoV-2 S-614G spike protein to human ACE2. The antibacterial activity of Lydimycin can be reversed by Biotin (HY-B0511) in the culture medium. Lydimycin is applicable to infection-related research[1][2].
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Lydimycin | Lydimycin (α-DHB; α-Dehydrobiotin) is an antibiotic produced by Streptomyces lydicus, with antibacterial, antifungal and antiviral activities. Lydimycin inhibits the binding of SARS-CoV-2 S-614G spike protein to human ACE2. The antibacterial activity of Lydimycin can be reversed by Biotin (HY-B0511) in the culture medium. Lydimycin is applicable to infection-related research. | |||||||||||||||||||||
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References
- [1]. Hanka L J, et al. Naturally Occurring Antimetabolite Antibiotic Related to Biotin. Science, 1966, 154(3757): 1667-1668.
- [2]. Sammons RM, et al. High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2. ACS infectious diseases. 2022 Nov 11;8(11):2259-2270. [Content Brief]
