101626-68-0
Chemical Structure
Nedocromil calcium
Synonym(s): FPL 59002 calcium
- CAS No.: 101626-68-0
- Formula:C19H15CaNO7
- Molecular Weight:409.40
InChIKey: FGUNXXYEYHFDNX-UHFFFAOYSA-L
SMILES: O=C(C(OC1=C2C=C3C(C=C(N(CC)C3=C1CCC)C([O-])=O)=O)=CC2=O)[O-].[Ca+2]
Biological Activity: Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis[1][2][3].
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Nedocromil calcium | Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis. | |||||||||||||||||||||
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References
- [1]. Levi-Schaffer F, et al. Nedocromil sodium ameliorates skin manifestations in a murine model of chronic graft-versus-host disease. Bone marrow transplantation. 1997 Apr;19(8):823-8.
- [2]. Vittori E, et al. Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells. The Journal of allergy and clinical immunology. 1992 Jul;90(1):76-84.
- [3]. Merayo-Lloves J, et al. A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium. The Journal of allergy and clinical immunology. 1996 May;97(5):1129-40.
