Nedocromil calcium
Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis.
For research use only. We do not sell to patients.
- CAS No.: 101626-68-0
- Formula: C19H15CaNO7
- Molecular Weight:409.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IL-1β |
IL-8 |
In Vitro
Nedocromil sodium (10-5 mol/L; 4 h) prevents the increased expression of IL-8 mRNA induced by IL-1β in cultured human bronchial epithelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neutrophils and human bronchial epithelial cells
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Concentration:up to 10^-5 mol/L
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Incubation Time:8 h
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Result:Did not significantly affect the chemotactic activity of epithelial cell-conditioned media at concentrations up to 10^-5 mol/L.
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Cell Line:Human bronchial epithelial cells
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Concentration:10^-5 mol/L (preincubation); 5 ng/mL (IL-1β)
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Incubation Time:3-5 h (preincubation); 8 h (IL-1β stimulation)
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Result:Reduced the release of immunoreactive IL-8 by >50% when added 3 to 5 hours before IL-1β.
Significantly reduced the release of immunoreactive IL-8 induced by IL-1β in a dose-dependent manner when preincubated for 4 hours.
Did not modify the constitutive release of IL-8 at concentrations up to 10^-5 mol/L.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 6-10 weeks, 20-25 g)[1]
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Dosage:5 mg/mouse
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Administration:i.p.; daily; 15 days
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Result:Decreased the mean dermis/fat ratio to 1.5 compared to 4.0 in saline-treated cGVHD mice.
Normalized skin mast cell numbers from 1.71 to 2.95.
Increased peritoneal mast cell numbers to 1.45 compared to 0.25 in controls.
Chemical Information
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CAS No. 101626-68-0
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Molecular Weight 409.40
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Formula C19H15CaNO7
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SMILES
O=C(C(OC1=C2C=C3C(C=C(N(CC)C3=C1CCC)C([O-])=O)=O)=CC2=O)[O-].[Ca+2]
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Synonyms
FPL 59002 calcium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nedocromil calcium Related Classifications
HY-13448A Related Classifications
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Keywords
- Nedocromil
- 101626-68-0
- FPL 59002
- FPL59002
- FPL-59002
- Interleukin Related
- IL-1β-induced IL-8 production
- human bronchial epithelial cells
- asthma
- mast cell stabilizer
- skin mast cell numbers
- mast cell degranulation
- IL-8 mRNA
- allergic conjunctivitis
- chronic graft-versus-host disease
- human neutrophils
- Inhibitor
- inhibitor
- inhibit