10465-81-3
Chemical Structure
1,1'-(Azodicarbonyl)-dipiperidine
Synonym(s): ADDP; SR 4077
- CAS No.: 10465-81-3
- Formula:C12H20N4O2
- Molecular Weight:252.31
IUPAC Name: (E)-diazene-1,2-diylbis(piperidin-1-ylmethanone)
InChIKey: OQJBFFCUFALWQL-BUHFOSPRSA-N
SMILES: O=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2
Biological Activity: 1,1'-(Azodicarbonyl)-dipiperidine (ADDP; SR 4077) is an oxidizing reagent for intracellular reducing agents and a chemical coupling reagent. 1,1'-(Azodicarbonyl)-dipiperidine exhibits biological activities such as pro-oxidation, radiosensitization, and induction of apoptosis, and can serve as a Mitsunobu reaction catalyst for chemical synthesis. 1,1'-(Azodicarbonyl)-dipiperidine oxidizes and depletes intracellular reducing pools such as GSH, leading to protein thiol oxidation and oxidative stress, thereby inhibiting DNA single-strand break repair or altering membrane function, ultimately mediating apoptosis signaling and increasing radiosensitivity. 1,1'-(Azodicarbonyl)-dipiperidine can be used in research on pulmonary arterial hypertension, lymphoma, and teratocarcinoma[1][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1,1'-(Azodicarbonyl)-dipiperidine | 97.0% | 1,1'-(Azodicarbonyl)-dipiperidine (ADDP; SR 4077) is an oxidizing reagent for intracellular reducing agents and a chemical coupling reagent. 1,1'-(Azodicarbonyl)-dipiperidine exhibits biological activities such as pro-oxidation, radiosensitization, and induction of apoptosis, and can serve as a Mitsunobu reaction catalyst for chemical synthesis. 1,1'-(Azodicarbonyl)-dipiperidine oxidizes and depletes intracellular reducing pools such as GSH, leading to protein thiol oxidation and oxidative stress, thereby inhibiting DNA single-strand break repair or altering membrane function, ultimately mediating apoptosis signaling and increasing radiosensitivity. 1,1'-(Azodicarbonyl)-dipiperidine can be used in research on pulmonary arterial hypertension, lymphoma, and teratocarcinoma. | ||||||||||||||||||||
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