105336-14-9
Chemical Structure
Azumolene sodium
Synonym(s): EU4093
- CAS No.: 105336-14-9
- Formula:C13H9BrN4NaO3
- Molecular Weight:372.13
IUPAC Name: (E)-1-(((5-(4-bromophenyl)oxazol-2-yl)methylene)amino)imidazolidine-2,4-dione, sodium salt
InChIKey: LPJVYINOPBXWDB-FPUQOWELSA-N
SMILES: O=C1NC(CN1/N=C/C2=NC=C(C3=CC=C(Br)C=C3)O2)=O.[Na]
Biological Activity: Azumolene sodium (EU4093) is an analog of Dantrolene (HY-12542) that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca2+ homeostasis failure caused by Halothane (HY-B1010)/Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca2+]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection[1].
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Azumolene sodium | Azumolene sodium (EU4093) is an analog of Dantrolene (HY-12542) that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca2+ homeostasis failure caused by Halothane (HY-B1010)/Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca2+]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection. | |||||||||||||||||||||
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