107110-16-7
Chemical Structure
Indigoticoside A
- CAS No.: 107110-16-7
- Formula:C26H34O11
- Molecular Weight:522.55
IUPAC Name: (2S,3R,4S,5S,6R)-2-(4-((2S,3R,4R)-4-(4-hydroxy-3-methoxybenzyl)-3-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: KNFOHFRALRKTOJ-SAOYRWCPSA-N
SMILES: C(O)[C@@H]1[C@H](OC[C@@H]1CC2=CC(OC)=C(O)C=C2)C3=CC(OC)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3
Biological Activity: Indigoticoside A is a phenylpropanoid lignan natural product that can be found in the traditional Chinese medicine Banlangen (Isatis indigotica Fort.), with antioxidant and anti-inflammatory activities. Indigoticoside A scavenges DPPH free radicals, superoxide anions and hydroxyl radicals in a dose-dependent manner, exhibiting significant in vitro antioxidant effects. The blood-absorbed components of Banlangen containing Indigoticoside A inhibit LPS (HY-D1056)-induced inflammatory responses in macrophages and reduce the production of inflammatory mediators such as NO, PGE2 and TNF-α[1][2].
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Indigoticoside A | Indigoticoside A is a phenylpropanoid lignan natural product that can be found in the traditional Chinese medicine Banlangen (Isatis indigotica Fort.), with antioxidant and anti-inflammatory activities. Indigoticoside A scavenges DPPH free radicals, superoxide anions and hydroxyl radicals in a dose-dependent manner, exhibiting significant in vitro antioxidant effects. The blood-absorbed components of Banlangen containing Indigoticoside A inhibit LPS (HY-D1056)-induced inflammatory responses in macrophages and reduce the production of inflammatory mediators such as NO, PGE2 and TNF-α. | |||||||||||||||||||||
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References
- [1]. Xiao P, et al. Ultrasound-assisted extraction coupled with SPE-HPLC-DAD for the determination of three bioactive phenylpropanoids from Radix Isatidis. Analytical methods : advancing methods and applications. 2014 Aug 22;6(18):7547-7553. [Content Brief]
- [2]. Xiao P, et al. In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion. Journal of ethnopharmacology. 2014 Nov 18;157:55-61. [Content Brief]
