Indigoticoside A
Indigoticoside A is a phenylpropanoid lignan natural product that can be found in the traditional Chinese medicine Banlangen (Isatis indigotica Fort.), with antioxidant and anti-inflammatory activities. Indigoticoside A scavenges DPPH free radicals, superoxide anions and hydroxyl radicals in a dose-dependent manner, exhibiting significant in vitro antioxidant effects. The blood-absorbed components of Banlangen containing Indigoticoside A inhibit LPS (HY-D1056)-induced inflammatory responses in macrophages and reduce the production of inflammatory mediators such as NO, PGE2 and TNF-α.
For research use only. We do not sell to patients.
- CAS No.: 107110-16-7
- Formula: C26H34O11
- Molecular Weight:522.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Indigoticoside A (50, 100, and 200 μg/mL; pretreated for 1 h followed by stimulation with LPS (HY-D1056) for 24 h) dose-dependently inhibits the production of NO, PGE2, and TNF-α in LPS-induced RAW264.7 cells. Among the samples, the IN sample exhibits the strongest inhibitory activity, while the OUT sample only shows weak or negligible inhibitory effects[2].
Indigoticoside A (7.89-91.17 μg/mL; 2 h), a component in the extract of *Isatis indigotica* Fort., has an in vitro bioaccessibility of 8.65% after simulated gastrointestinal digestion. This component shows stable recovery in the gastric environment, while its total recovery increases slightly in the intestinal environment, suggesting that it can be biotransformed from clemastanin B[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW264.7 cells
-
Concentration:0, 50, 100 and 200 μg/mL
-
Incubation Time:24 h
-
Result:Showed no notable cytotoxicity and slightly increased cell proliferation at concentrations up to 200 μg/mL.
Chemical Information
-
CAS No. 107110-16-7
-
Molecular Weight 522.55
-
Formula C26H34O11
-
SMILES
C(O)[C@@H]1[C@H](OC[C@@H]1CC2=CC(OC)=C(O)C=C2)C3=CC(OC)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xiao P, et al. Ultrasound-assisted extraction coupled with SPE-HPLC-DAD for the determination of three bioactive phenylpropanoids from Radix Isatidis. Analytical methods : advancing methods and applications. 2014 Aug 22;6(18):7547-7553. [Content Brief]
[2]. Xiao P, et al. In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion. Journal of ethnopharmacology. 2014 Nov 18;157:55-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indigoticoside A Related Classifications
HY-N17277 Related Classifications
Powered by Bioz