1090528-71-4
Chemical Structure
(Rac)-T6167923
- CAS No.: 1090528-71-4
- Formula:C17H20BrN3O3S2
- Molecular Weight:458.39
IUPAC Name: 4-((3-bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide
InChIKey: PNTQVMBKHCOLQD-UHFFFAOYSA-N
SMILES: O=C(NC(C=1SC=CC1)C)N2CCN(CC2)S(=O)(=O)C=3C=CC=C(Br)C3
Biological Activity: (Rac)-T6167923 is the racemic form of T6167923 (HY-19744) and acts as a MyD88 inhibitor. (Rac)-T6167923 disrupts MyD88 homodimer formation and blocks MyD88-dependent signaling, thereby inhibiting TLR2/MyD88 downstream NF-κB activation and pro-inflammatory cytokine production. (Rac)-T6167923 modulates macrophage inflammatory responses and polarization states, and reduces the survival rate of Mycobacterium avium subsp. paratuberculosis (MAP) within infected macrophages. (Rac)-T6167923 can be used for research related to inflammatory responses and mycobacterial infections[1][2].
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(Rac)-T6167923 | (Rac)-T6167923 is the racemic form of T6167923 (HY-19744) and acts as a MyD88 inhibitor. (Rac)-T6167923 disrupts MyD88 homodimer formation and blocks MyD88-dependent signaling, thereby inhibiting TLR2/MyD88 downstream NF-κB activation and pro-inflammatory cytokine production. (Rac)-T6167923 modulates macrophage inflammatory responses and polarization states, and reduces the survival rate of Mycobacterium avium subsp. paratuberculosis (MAP) within infected macrophages. (Rac)-T6167923 can be used for research related to inflammatory responses and mycobacterial infections. | |||||||||||||||||||||
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References
- [1]. AlQasrawi D, et al. Nicotine Modulates MyD88-Dependent Signaling Pathway in Macrophages during Mycobacterial Infection. Microorganisms. 2020 Nov 17;8(11):1804.
- [2]. Grey EL, et al. A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response. Journal of controlled release : official journal of the Controlled Release Society. 2026 Jul 31;398:115225.
