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Cat. No.: HY-19744A

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(Rac)-T6167923

(Rac)-T6167923 is the racemic form of T6167923 (HY-19744) and acts as a MyD88 inhibitor. (Rac)-T6167923 disrupts MyD88 homodimer formation and blocks MyD88-dependent signaling, thereby inhibiting TLR2/MyD88 downstream NF-κB activation and pro-inflammatory cytokine production. (Rac)-T6167923 modulates macrophage inflammatory responses and polarization states, and reduces the survival rate of Mycobacterium avium subsp. paratuberculosis (MAP) within infected macrophages. (Rac)-T6167923 can be used for research related to inflammatory responses and mycobacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1090528-71-4
Formula: C₁₇H₂₀BrN₃O₃S₂
Molecular Weight:458.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-T6167923 Chemical Structure

CAS No.: 1090528-71-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Innate ImmunityCytokines and ChemokinesBacterial Infection

Innate Immunity

Cytokines and Chemokines

(Rac)-T6167923 (0-20 µg/mL; 30 min preincubation, 24 h infection) decreases iNOS, TNF-α, and IL-8 expression and modulates MMR expression in PMA-differentiated THP-1 macrophages; at 10 μg/mL, TNF-α and IL-8 expression decrease to 1.15-fold and 1.10-fold, respectively, and MMR increases from 0.71-fold with MAP infection alone to 0.92-fold^[1].
(Rac)-T6167923 (10 μg/mL; MAP infection; 24 h) reduces iNOS and IL-8 expression to levels comparable to those in uninfected cells in THP-1-derived macrophages, while promoting M2-related MMR expression and increasing IL-10; under combined conditions, IL-10 increases 2.5-fold compared with MAP infection alone^[1].

Bacterial Infection

(Rac)-T6167923 (10 μg/mL; MAP infection; 48 h) reduces intracellular MAP survival to 55% at 48 h in THP-1-derived macrophages^[1].

Innate Immunity

(Rac)-T6167923 (1-500 μM; PAM3CSK4 (HY-P1180) 100 ng/mL; 24 h) concentration-dependently inhibits NF-κB activation in RAW-Blue macrophages; at 100 and 500 μM, NF-κB activation is reduced by 40% and 50%, respectively^[2].

Cytokines and Chemokines

(Rac)-T6167923 (0.05-200 μM; PAM3CSK4 50 ng/mL; 8 h) decreases IL-6 production in a concentration-dependent manner in RAW 264.7 macrophages; at 100 μM it reduces IL-6 by 89%, and at 150 and 200 μM IL-6 levels decrease by 15-fold and 19-fold, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

THP-1 macrophages
Concentration:

0, 2.5, 5, 10, 20 µg/mL
Incubation Time:

30 min (preincubation); 24 h (infection)
Result:

Decreased iNOS, TNF-α and IL-8 expression.
At 10 μg/mL, decreased TNF-α and IL-8 expression to 1.15- and 1.10-fold, respectively.
Increased MMR from 0.71-fold with MAP alone to 0.92-fold at 10 μg/mL.

RT-PCR^[1]

Cell Line:

THP-1 macrophages
Concentration:

10 µg/mL
Incubation Time:

24 h
Result:

Reduced iNOS and IL-8 expression to near uninfected-cell levels.
Increased M2-associated MMR and IL-10.
Increased IL-10 by 2.5-fold versus MAP infection alone under the combined condition.

ELISA Assay^[2]

Cell Line:

RAW 264.7 macrophages
Concentration:

0.05, 50, 100, 150, 200 μM
Incubation Time:

PAM3CSK4 50 ng/mL; 8 h
Result:

Dose-dependently reduced IL-6 production.
Reduced IL-6 by 89% at 100 μM.
Decreased IL-6 levels by 15-fold at 150 μM and by 19-fold at 200 μM.

Related Protocols :

Chemical Information

CAS No. 1090528-71-4
Molecular Weight 458.39
Formula C₁₇H₂₀BrN₃O₃S₂
SMILES

O=C(NC(C=1SC=CC1)C)N2CCN(CC2)S(=O)(=O)C=3C=CC=C(Br)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. AlQasrawi D, et al. Nicotine Modulates MyD88-Dependent Signaling Pathway in Macrophages during Mycobacterial Infection. Microorganisms. 2020 Nov 17;8(11):1804.

[2]. Grey EL, et al. A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response. Journal of controlled release : official journal of the Controlled Release Society. 2026 Jul 31;398:115225.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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