1112169-64-8
Chemical Structure
MMP13-IN-7
- CAS No.: 1112169-64-8
- Formula:C21H24FN7O5
- Molecular Weight:473.46
IUPAC Name: N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide
InChIKey: SKEAGJWUKCNICJ-LSDHHAIUSA-N
SMILES: O=C(C1=NC(C)=NC(C2=NN(C[C@@H]3OC[C@@H](CO)OC3)N=N2)=C1)NCC4=CC=C(F)C(OC)=C4
Biological Activity: MMP13-IN-7 is an orally active MMP-13 inhibitor with a Ki value of 1.5 nM. MMP13-IN-7 targets the zinc-dependent protease MMP-13 that cleaves type II collagen. MMP13-IN-7 reduces elevated type II collagen neoepitope levels and the severity of osteoarthritis-like joint lesions in a canine meniscectomy model. MMP13-IN-7 can be used for research on osteoarthritis[1].
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MMP13-IN-7 | MMP13-IN-7 is an orally active MMP-13 inhibitor with a Ki value of 1.5 nM. MMP13-IN-7 targets the zinc-dependent protease MMP-13 that cleaves type II collagen. MMP13-IN-7 reduces elevated type II collagen neoepitope levels and the severity of osteoarthritis-like joint lesions in a canine meniscectomy model. MMP13-IN-7 can be used for research on osteoarthritis. | |||||||||||||||||||||
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References
- [1]. Ruminski PG, et al. Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59(1):313-27. [Content Brief]
