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Cat. No.: HY-11037

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MMP13-IN-7

MMP13-IN-7 is an orally active MMP-13 inhibitor with a K_i value of 1.5 nM. MMP13-IN-7 targets the zinc-dependent protease MMP-13 that cleaves type II collagen. MMP13-IN-7 reduces elevated type II collagen neoepitope levels and the severity of osteoarthritis-like joint lesions in a canine meniscectomy model. MMP13-IN-7 can be used for research on osteoarthritis.

For research use only. We do not sell to patients.

CAS No.: 1112169-64-8
Formula: C₂₁H₂₄FN₇O₅
Molecular Weight:473.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MMP13-IN-7 Chemical Structure

CAS No.: 1112169-64-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

MMP13

All MMP Isoforms :

In Vitro

MMP13-IN-7 (Compound 43a) is highly selective against MMP-3 and a panel of matrix metalloproteinases, TACE, and aggrecanase. MMP13-IN-7 inhibits cytokine-induced generation of type II collagen neoepitope in human articular cartilage.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Parmacokinetics

Species	Dose	Route	CL	F
Rat^[1]	1.0 mg/kg	i.v.	18.2 mL/min/kg	/
Rat^[1]	1.0 mg/kg	p.o.	/	95 %
Dog^[1]	1.0 mg/kg	p.o.	8.2 mL/min/kg	64 %

Chemical Information

CAS No. 1112169-64-8
Molecular Weight 473.46
Formula C₂₁H₂₄FN₇O₅
SMILES

O=C(C1=NC(C)=NC(C2=NN(C[C@@H]3OC[C@@H](CO)OC3)N=N2)=C1)NCC4=CC=C(F)C(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ruminski PG, et al. Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59(1):313-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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