1135364-14-5
1135364-14-5
Chemical Structure
Z-Nle-Lys-Arg-AMC
- CAS No.: 1135364-14-5
- Formula:C36H50N8O7
- Molecular Weight:706.83
InChIKey: NORKJDJOQHFBSO-AWCRTANDSA-N
SMILES: CCCC[C@@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC1=CC(O2)=C(C=C1)C(C)=CC2=O)=O)=O)CCCCN)=O)NC(OCC3=CC=CC=C3)=O
Biological Activity: Z-Nle-Lys-Arg-AMC is a selective Fluorescent peptide substrate for Cathepsin B. Z-Nle-Lys-Arg-AMC releases AMC upon cleavage, thereby enabling monitoring of proteolytic activity over an acidic to neutral pH range[1][2][3][4].
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Z-Nle-Lys-Arg-AMC | Z-Nle-Lys-Arg-AMC is a selective Fluorescent peptide substrate for Cathepsin B. Z-Nle-Lys-Arg-AMC releases AMC upon cleavage, thereby enabling monitoring of proteolytic activity over an acidic to neutral pH range. | |||||||||||||||||||||
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References
- [1]. Phan VV. Targeting Cytosolic Cathepsin B: Leveraging pH-Dependent Cleavage Preferences with Selective Inhibitors to Rescue Cell Death and Mitigate TBI-Induced Motor Deficits (Doctoral dissertation, et al.
- [2]. Liolios C, et al. Prodrugs targeting prostate-specific membrane antigen against prostate cancer. Journal of Medicinal Chemistry. 2025 Jun 12;68(12):12296.
- [3]. Yoon MC, et al. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 Aug 01;62(15):2289-2300. [Content Brief]
- [4]. Podvin S, et al. Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK. ACS chemical neuroscience. 2025 Apr 02;16(7):1297-1308. [Content Brief]
